Lion's Mane Mushroom (Hericium erinaceus) and Nerve Regeneration

By Dr. Markho Rafael


Out of the kitchen, into the pharmacy, the gourmet mushroom Lion's Mane (Hericium erinaceus) with its unique flavor resembling lobster or shrimp appears to also possess likewise unique medicinal properties. It has been found to stimulate nerve and myelin regeneration, which may be beneficial in many neurological conditions. World renowned medicinal mushroom expert Paul Stamets suggests its potential application in conditions such as Alzheimer's, dementia, multiple sclerosis and muscular dystrophy. (134)

Hericium erinaceus (Lion's Mane) is known to grow in Europe, North America, Japan and China. It can be found on many broad leaf trees, from oaks, maples and sycamores to beeches and walnuts.

The active compounds that have received the most attention for their nerve regenerating properties are named erinacines, a series of low molecular weight molecules that are able to pass through the blood brain barrier - an essential attribute for any medicinal compound expected to be able to effect healing on myelin or nerve tissue. (152, 153, 154)

Two Japanese patents exist relating to Hericium erinaceus extracts; one from the 1990's for an extraction process of these compounds yielding an extract known as "Nerve Growth Stimulant Factor." (150, 151) A more recent one from 2004 is for a water extract of Hericium erinaceus, also used for its nerve regenerating properties. (155)

Although recent research on Hericium erinaceus extract has focused on its powerful effect on healing nerve tissue, in Traditional Chinese Medicine Lion's Mane Mushroom was used primarily for stomach conditions and cancers of the digestive organs.

Modern studies have affirmed the validity of this traditional application of Hericium erinaceus extract. One paper published in 1985 reported positive findings in the treatment of atrophic gastritis. Another from 1995 concluded that Hericium erinaceus had an ameliorating effect on hepatoma with an increased life expectancy for treated patients. (156)

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Always consult a licensed medical practitioner before using any herb (or mushroom) for medicinal purposes.

Credits: Thank you, Paul Stamets, for research references.




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